 |  | | | | | (2S)-OMPT | Phospholipids | | Reference 10005707 |  |
| | | Data |  | Molecular Formula | C22H43O6PS · 2(C2H5)3N | | Formulation | A solution in ethanol:chloroform (1:1) | | Purity | >98% | | Stability | 1 year | | Storage | -20°C | | Shipping | WET ICE | | Correlated Keywords | GPR, lysophosphatidic, acids, lipids, mediators, receptors, LPA1/Edg-2, LPA2/Edg-4, LPA3/Edg-7, LPA4/GPR23, agonists, calcium, mobilization, Sf9, cells, (2R)-OMPT, release, assays, LPA3-transfected, rat, hepatoma, Rh7777 |
| | | Description | Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23. OMPT is a selective agonist of the LPA3 receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA3 and LPA2-expressing Sf9 cells, respectively. The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. | | | Related Products | | | | Documentation | | | | | | Hasegawa, Y., Erickson, J.R., Goddard, G.J., et al. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. J Biol Chem 278(14) 11962-11969 (2003). | | Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002). | | Qian, L., Xu, Y., Hasegawa, Y., et al. Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem 46 5575-5578 (2003). | | Niu, S., Mitchell, D.C., Litman, B.J. Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. Biochemistry 44 4458-4465 (2005). |
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