 |  | | | | | (+)-Catechin (hydrate) | Flavonoids | | Reference 70940 |  |
| | | Data |  | CAS number | 88191-48-4 | | Molecular Formula | C15H14O6 · H2O | | Formulation | A crystalline solid | | Purity | >98% | | Lambda Max | 230, 280 nm | | Stability | 2 years | | Storage | 4°C | | Shipping | WET ICE | | Correlated Keywords | polyphenolic, flavonoids, antioxidants, lipid, peroxidation, oxidative, injury, stress, inhibitors, inhibits, COX-1, COX1, PGHS-1, PGHS2, cyclooxygenases, prostaglandin, synthases, cyclooxygenase-2, synthase-2, antitumor, procyanidin, d-catechin, inhibition, hydrates | | Synonyms | D-(+)-Catechin (hydrate), Cyanidol (hydrate), Catechuic Acid (hydrate) |
| | | Description | Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro assays of lipid peroxidation. Catechin inhibits the free radical-induced oxidation of isolated LDL by AAPH. It has also been reported to act as an inhibitor of COX-1 with an IC50 of about 80 µM. Catechin and other related procyanidin compounds have antitumor activity when tested in a two-stage mouse epidermal carcinoma model employing topical application. | | | Related Products | | | | Documentation | | | | | | Frémont, L., Belguendouz, L., Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999). | | Zhao, J., Wang, J., Chen, Y., et al. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis 20 1737-1745 (1999). | | Noreen, Y., Serrano, G., Perera, P. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalyzed prostaglandin biosynthesis. Planta Med 64 520-524 (1998). |
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