 |  | | | | | (R)-Bromoenol lactone | Phospholipase | | Reference 10006800 |  |
| | | Data |  | CAS number | 478288-90-3 | | Molecular Formula | C16H13BrO2 | | Formulation | A solution in methyl acetate | | Purity | ≥98% | | Lambda Max | 222, 280 nm | | Stability | 1 year | | Storage | -20°C | | Shipping | WET ICE | | Correlated Keywords | selective, iPLA2, inhibitors, phospholipases, PLAs, BEL, iPLA2b, iPLA2β, iPLA2g, iPLA2γ, lipids, hydrolases, cells, signaling, digestion, membrane, remodeling, venom, calcium, independent, releases, AA, arachidonic, acids, physiologic, stimuli, irreversible, chiral, mechanism-based, human, recombinants | | Synonyms | (R)-BEL |
| | | Description | The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2γ. Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM. (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM. | | | Related Products | | | | Documentation | | | | | | Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol 39 175-189 (1999). | | Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. J Biol Chem 277(36) 32807-32814 (2002). |
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