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(-)-(α)-Kainic Acid
unclassified
Reference 78050
Data
CAS number487-79-6
Molecular FormulaC10H15NO4
FormulationA crystalline solid
Purity>98%
Stability2 years
StorageRoom temperature
ShippingAMBIENT
Correlated Keywordsneuroexcitatory, seizures, neuroexcitotoxics, epileptogenics, alga, algae, neurochemistry, neuroscience
Description
Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice. Kainic acid is neuroexcitotoxic and epileptogenic, acting through specific kainate receptors.
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Documentation
Marsicano, G., Goodenough, S., Monory, K., et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302 84-88 (2003).
Ferkany, J.W., Zaczek, R., Coyle, J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298(19) 757-759 (1982).
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