 |  | | | | | (3S)-3-Hydroxyquinine (3-OHquinine) | Chemicals.metabolites | | Reference M02010 |  |
| | | Data |  | CAS number | 78549-61-8 | | Sub category | Metabolites | | Molecular Formula | C20H24N2O3 | | Molecular Weight | 340.4 | | Stability | ≥ 1 year | | Purity | ≥ 97% | | Application | CYP3A4 metabolite of Quinine | | Storage | + 4°C | | Shipping | Wet Ice | | Contents | 1 ea | | Correlated Keywords | metabolites, metabolism, CYP450, CYP-450-3A4, CYP-3A4, CYP3A4, cytochromes, M02010 |
| | | Documentation | | | | | | Confirmation of the structure of (3S)-3-hydroxyquinine : synthesis and X-ray crystal structure of its 9-aceto analogue.
Srirama Sarma PVV et al. J.Nat.Prod. 68, 942-944 (2005). | | Enzyme Kinetics for the Formation of 3-Hydroxyquinine and three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway.
Mirghani RA et al. Drug Metab. Disp. 30 (12), 1368-1371(2002). | | Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
Zhao XJ et al. J Pharmacol Exp Ther. 279(3), 1327-1334 (1996).Siebers-Wolff S et al. Microbiological hydroxylation and N-oxidation of cinchona alkaloids, Biocatalysis 8, 47-58 (1993). |
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