(-)-CP 47,497

Cannabinoids
Reference 13218

Data

	CAS number	114753-51-4
	Molecular Formula	C21H34O2
	Formulation	A crystalline solid
	Purity	≥98%
	Stability	2 years
	Storage	-20°C
	Shipping	WET ICE
	Correlated Keywords	cannabinoids, analgesia, CB1, hypothermia, motor, deppressant, anticonvulsant, Δ9-THC, analogs, activity, hypothermic, effects

Description

CP 47,497 is a bicyclic cannabinoid (CB) analog with potent analgesic activity. It is comparable or more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice, rats, and dogs. The levorotatory enantiomer, (-)-CP 47,497 avidly binds the CB1 receptor (Ki = 2.1 nM).

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Documentation

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Articles

	Weissman, A., Milne, G.M., Melvin, L.S. Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. J Pharmacol Exp Ther 223(2) 516-523 (1982).
	Melvin, L.S., Milne, G.M., Johnson, M.R., et al. Structure-activity relationships defining the ACD-tricyclic cannabinoids: Cannabinoid receptor binding and analgesic activity. Drug Design Discov 13 155-166 (1995).
	Melvin, L.S., Johnson, M.R., Harbert, C.A., et al. A cannabinoid derived prototypical analgesic. J Med Chem 27 67-71 (1984).

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