 |  | | | | | (-)-Blebbistatin | Inhibitors | | Reference 13013 |  |
| | | Data |  | CAS number | 856925-71-8 | | Molecular Formula | C18H16N2O2 | | Formulation | A crystalline solid | | Purity | ≥98% | | Stability | 2 years | | Storage | -20°C | | Shipping | Wet Ice | | Correlated Keywords | inhibitors, muscles, myosin, ATPase, smooth, muscle, bleb, apoptosis, cell, migration, chemotaxis, cytokinesis, cells, division, growth, UV, light, blebs, (-)-(S)-Blebbistatin | | Synonyms | (S)-Blebbistatin |
| | | Description | (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light, which may be particularly important in fluorescent cell imaging applications. | | | Related Products | | | | Documentation | | | | | | Limouze, J., Straight, A.F., Mitchison, T., et al. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil 25 337-341 (2004). | | Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun 320 1020-1025 (2004). | | Straight, A.F., Cheung, A., Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743-1747 (2003). | | Kovács, M., Tóth, J., Hetényi, C., et al. Mechanism of blebbistatin inhibition of myosin II. J Biol Chem 279(34) 35557-35563 (2004). | | Harb, N., Archer, T.K., Sato, N. The Rho-rock-myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells. PLoS One (2008). |
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